DNA damage responses include the activation of cell cycle checkpoints, the activation of apoptosis, and the activation of DNA damage tolerance. This last mechanism allows a cell to “accept” DNA damage and continue DNA replication even in the setting of a heightened mutation frequency.
A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle ...
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Oct 24, 2018 · DNA damage response (DDR) pathways mitigate replication stress and repair DNA; thus, deficiencies in these pathways result in the accumulation ...
To repair these DNA damage events and enable cells to function normally, a series of processes takes place, collectively known as the DNA Damage Response (DDR).
Dec 5, 2022 · Cells have evolved a complex network of biochemical pathways, collectively known as the DNA damage response (DDR), to prevent detrimental ...
Jul 29, 2021 · Cells respond to genotoxic stress through a series of complex protein pathways called DNA damage response (DDR). These monitoring mechanisms ...
In addition to checkpoint activation, the DNA damage response leads to induction of transcriptional programs, enhancement of DNA repair pathways, and when the ...
The DNA damage response during DNA replication ... Eukaryotic chromosome replication is mediated by multiple replicons and is coordinated with sister chromatid ...
Jun 11, 2020 · Explore how various cellular DNA damage response (DDR) and DNA repair pathways are targeted to develop novel anticancer therapeutic strategies.
Oct 8, 2020 · The study aim was to investigate the association between DNA damage response (DDR), replication stress, and novel therapeutic response in PC to ...